The β-lactam adjuvant guanosine potentiates anti-folate antibiotics and pyrimidine synthesis inhibitors by depleting thymidine in methicillin-resistant Staphylococcus aureus
Aaron Christopher Nolan, Jessica Blaise Kelly, Jongsam Ahn, Dhananjay Shinde, Vinai Chittezham Thomas, Merve Suzan Zeden, James P. O’Gara
This paper shows that guanosine, a β-lactam adjuvant, enhances the effectiveness of antifolate antibiotics and pyrimidine inhibitors by depleting thymidine in MRSA.
Antimicrobial Agents and Chemotherapy · Jun 10, 2026Peer-reviewedMicrobiology