Noa Lipstein

This study identifies TDP-43-dependent cryptic splicing events in synaptic and membrane excitability genes and shows they drive neuronal dysfunction in ALS and FTD.

This study uses proximity labelling to map the proteome of different compartments in murine sensory neurons, revealing compartment-specific proteomic changes in a neuropathy model.

The paper introduces a one-step method to create cell-impermeable fluorescent HaloTag substrates for live-cell imaging and super-resolution microscopy.

This study shows that peroxisome dysfunction in mice and engineered human myocardium leads to heart failure through metabolic impairment and disrupted cellular respiration.

This paper introduces a knock-in mouse line with endogenous Munc13-1-SNAP for monitoring presynaptic nanoarchitecture using SNAP-tag labeling and live-cell imaging.

The paper characterizes a VGLUT1 knock-down mouse model and finds that reduced VGLUT1 expression does not significantly affect quantal size or frequency of glutamate release.

This study shows ketamine increases presynaptic glutamate release in cerebellar synapses by enhancing calcium influx and vesicle readiness, suggesting a direct presynaptic mechanism for its antidepressant effects.

The paper investigates the opposing roles of Munc13-1 and ubMunc13-2 in dense-core vesicle secretion in response to phorbolesters, showing that ubMunc13-2 promotes secretion while Munc13-1 inhibits it, with syt7 mediating the stimulatory effect of phorbolesters.

The paper identifies key proteins and domains involved in dopamine release in the striatum, showing that RIM, Munc13, and Liprin- are essential while other active zone proteins are not.