Jan Brugués A

Robust cytoplasmic partitioning by solving an intrinsic cytoskeletal instability

The paper demonstrates how embryos use microtubule dynamics and temporal control to achieve robust cytoplasmic partitioning through two distinct strategies in zebrafish and Drosophila.

Active Loop Extrusion guides DNA-Protein Condensation

This study investigates how DNA loop extrusion interacts with protein-DNA condensation, showing that loop extrusion enhances condensation dynamics and leads to domain formation similar to TADs.

The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos

The paper shows that spindle length and the cell cycle oscillator regulate the speed of chromosome separation during Drosophila blastoderm cleavage divisions.

Nuclear partitioning by surface condensation on metaphase chromatids

The paper shows that H1.8 and NPM1 partition into the nucleus via surface condensation, independent of nuclear import and DNA-to-cytoplasm ratio.

Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

The paper shows that osteoclast-mediated resorption of calcified tissue is essential for successful skeletal integration during axolotl limb regeneration.