David Oriola

This study investigates how varying proportions of primed and naive ESCs affect gastruloid formation and AP axial patterning, revealing developmental flexibility in mammalian embryogenesis.

The paper shows that collective cell fate decisions and mechanical differences drive symmetry breaking in gastruloids through a mechanochemical mechanism.

The paper shows that osteoclast-mediated resorption of calcified tissue is essential for successful skeletal integration during axolotl limb regeneration.

This paper introduces a Bayesian deconvolution method to separate signal from noise in single-cell measurements, applied to study Brachyury expression in differentiating mouse embryonic stem cells.

The paper studies AP axis establishment in gastruloids using scRNA-seq and identifies molecular signatures of germ layer commitment and differences between Bra/T+ and Bra/T- populations.