Susan G. Campbell

STMN2 protein depletion via translation deficits and stress granules and its compensation in ALS

This study identifies TDP-43-independent mechanisms of STMN2 depletion in ALS, showing acute stress causes proteasomal degradation and translational repression, while chronic stress leads to reduced protein levels, with mRNA upregulation as a compensatory mechanism in some subtypes.

eIF2Bα subcellular localisation - a potential link between translation initiation and stress granule formation?

This study investigates eIF2B subunit localization and its role in stress granule formation, showing eIF2B's dual role in maintaining complex integrity and regulating stress responses.

Genetic Causes of early onset Ataxia: Experience from the National Sheffield Paediatric Ataxia Centre.

The paper analyzes genetic causes of early onset ataxia in 704 pediatric patients, finding Friedriechs ataxia and CACNA1A mutations as the most common genetic causes.

GRASPS: a simple-to-operate translatome technology reveals omics-hidden disease-associated pathways in TDP-43-related amyotrophic lateral sclerosis

GRASPS identifies more differentially expressed transcripts with higher fold changes and significance in TDP-43 ALS models, revealing previously missed disease pathways.