Author

Matthew Nolan

Harvard UniversityORCID 0000-0002-7204-5385Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Matthew Nolan1 paper · University of Minnesota Morris

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Clotilde Lagier‐TourenneiD· 3 shared Chao-Zong LeeiD· 2 shared Aaron HeldiD· 1 shared Ana Rita Agra de Almeida QuadrosiD· 1 shared Anna Sanchez Avila· 1 shared August Yue HuangiD· 1 shared Ayub BoulosiD· 1 shared Benjamin P. KleinstiveriD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersNeuroscience

Clotilde Lagier‐TourenneORCID

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Author profile →

3 papers

Recent·Most cited

Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative program

Matthew Nolan, Sandeep Aryal, I. Sandra Ndayambaje, Maize Cao, Peyton Lee, Moriah J. Hovde, Shuqi Yun, Josette J Wlaschin, Aaron Held, Hortense D. A. M. Beaussant, Benjamin Wymann, Chao-Zong Lee, Su Min Lim, Xin Jiang, Nandini Ramesh, , Clotilde Lagier‐Tourenne

The paper shows statins and mevalonate pathway inhibition increase STMN2 and ATF3, promoting neuronal regeneration in neurodegenerative disease.

bioRxiv · Feb 24, 2026 · PreprintNeuroscience

STMN2 protein depletion via translation deficits and stress granules and its compensation in ALS

Brittany C. S. Ellis, Anna Sanchez Avila, Wan-Ping Huang, Sabin J. John, Sam Bonsall, Rachel E. Hodgson, Vedanth Kumar, Matthew Nolan, Susan G. Campbell, Kurt J. De Vos, Clotilde Lagier‐Tourenne, J. Robin Highley, Johnathan Cooper‐Knock, Tatyana A. Shelkovnikova

This study identifies TDP-43-independent mechanisms of STMN2 depletion in ALS, showing acute stress causes proteasomal degradation and translational repression, while chronic stress leads to reduced protein levels, with mRNA upregulation as a compensatory mechanism in some subtypes.

bioRxiv · Jan 26, 2026 · PreprintCell Biology

Somatic mosaicism in amyotrophic lateral sclerosis and frontotemporal dementia identifies focal mutations associated with widespread degeneration

Zinan Zhou, Junho Kim, August Yue Huang, Matthew Nolan, Junseok Park, Ryan N. Doan, Taehwan Shin, Michael B. Miller, Mingyun Bae, Boxun Zhao, Jinhyeong Kim, Brian H. Chhouk, Katherine S. Morillo, Rebecca C. Yeh, Connor J. Kenny, , Christopher A. Walsh

The paper identifies rare somatic mutations in sporadic ALS and FTD cases, suggesting they contribute to disease and widespread neurodegeneration.

bioRxiv · Nov 30, 2023 · PreprintGenetics