Sarah M Chang

Cysteine-mediated bortezomib resistance is governed by α-ketoacid availability

This study shows that α-ketoacids enhance the effectiveness of bortezomib by reducing cysteine-mediated detoxification, thereby increasing proteasome inhibition and cytotoxicity.

Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

The paper shows cancer cells adjust mitochondrial respiration to alter NAD+/NADH ratios, enhancing biomass synthesis and proliferation under nutrient limitation.

Distinct neuronal activity patterns induce different gene expression programs

The paper shows that distinct neuronal activity patterns induce different gene expression programs through specific mechanisms.

Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans

This study shows that mitochondrial sirtuins sir-2.2 and sir-2.3 in C. elegans extend lifespan when fed E. coli OP50 but not HT115, with diet-dependent changes in oxidative stress gene expression.