Ralf Ewert

Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosis

This study compares IFNγ-induced iNOS activity in human and murine tuberculosis models, finding minimal iNOS expression in human myeloid cells and identifying epithelial cells as primary iNOS sources.

SNPs associated with HHIP expression have differential effects on lung function in males and females

The paper identifies SNPs with sex-specific effects on lung function traits using UK Biobank data, finding a significant interaction at rs7697189 near HHIP.

Expanded genetic landscape of chronic obstructive pulmonary disease reveals heterogeneous cell type and phenotype associations

This study expands the genetic landscape of COPD by identifying 82 risk loci, revealing associations with lung function, cell types, and comorbidities.

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.