Author

Susmita Malwade

Karolinska InstitutetORCID 0000-0002-6756-018XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Approach:experimental assay· 1

Frequent Co-Authors

Carl M. SellgreniD· 3 shared Samudyata SamudyataiD· 3 shared Ana Osório OliveiraiD· 2 shared Funda OrhaniD· 2 shared Jari KoıstınahoiD· 2 shared Jari TiihoneniD· 2 shared Marja KoskuviiD· 2 shared Šárka LehtoneniD· 2 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersNeuroscience

Carl M. SellgrenORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 24, 2025

A schizophrenia-associated radial glia cell state perturbs early human brain development

Susmita Malwade, Samudyata Samudyata, Jessica Gracias Lekander…·Carl M. Sellgren

This study identifies a schizophrenia-associated radial glia cell state that disrupts early human brain development through single-cell transcriptomic and epigenomic analyses of organoids.

DOI 10.1101/2025.10.24.684395

humanscRNA-seq

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NeurosciencebioRxivPreprintOct 19, 2023

Kynurenic acid promotes activity-dependent synaptic pruning in schizophrenia

Funda Orhan, Susmita Malwade, Neda Khanlarkhani…·Carl M. Sellgren

This study shows that kynurenic acid promotes microglia-mediated synaptic pruning in schizophrenia by reducing neuronal activity and linking genetic risk variants to KYNA production.

5 citations

humanbulk RNA-seq

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NeuroscienceMolecular PsychiatryPeer-reviewedOct 1, 2022

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

Samudyata Samudyata, Ana Osório Oliveira, Susmita Malwade…·Carl M. Sellgren

This study shows SARS-CoV-2 infection in human brain organoids leads to microglial synapse elimination, linking it to potential cognitive impairments post-COVID-19.

123 citationstop 1%

humanbulk RNA-seq

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NeuroscienceMolecular PsychiatryPeer-reviewedOct 8, 2019

Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

Navneet A. Vasistha, Maria Pardo-Navarro, Janina Gasthaus…·Konstantin V. Khodosevich

This study shows maternal inflammation impairs specific stages and subtypes of cortical GABAergic interneuron development, leading to structural and functional changes in the offspring's brain.

92 citationstop 5%

mouse

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