Funda Orhan

The paper investigates microglial dysfunction in anorexia nervosa using patient-derived iPSCs and an animal model, finding altered synaptic interactions and signaling in hypothalamic circuits.

This study shows that kynurenic acid promotes microglia-mediated synaptic pruning in schizophrenia by reducing neuronal activity and linking genetic risk variants to KYNA production.

This study shows SARS-CoV-2 infection in human brain organoids leads to microglial synapse elimination, linking it to potential cognitive impairments post-COVID-19.

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

This study uses diffusion tensor imaging and machine learning to predict brain age in schizophrenia and bipolar disorder patients, finding age overestimation in both groups compared to controls.