Carl M. Sellgren

This study identifies developmentally-regulated alternative splicing of CACNA1C during human neurodevelopment and shows it affects CaV1.2 channel function.

The paper investigates microglial dysfunction in anorexia nervosa using patient-derived iPSCs and an animal model, finding altered synaptic interactions and signaling in hypothalamic circuits.

This study compares thalamic nucleus volumes across multiple psychiatric and neurological disorders using MRI, finding significant volume reductions in specific regions associated with different conditions.

This study identifies a schizophrenia-associated radial glia cell state that disrupts early human brain development through single-cell transcriptomic and epigenomic analyses of organoids.

This study shows that kynurenic acid promotes microglia-mediated synaptic pruning in schizophrenia by reducing neuronal activity and linking genetic risk variants to KYNA production.

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

This study shows SARS-CoV-2 infection in human brain organoids leads to microglial synapse elimination, linking it to potential cognitive impairments post-COVID-19.

This study generates patient-derived microglia-like cells from umbilical cord blood to model fetal brain immune responses to maternal SARS-CoV-2 exposure.

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

This study uses diffusion tensor imaging and machine learning to predict brain age in schizophrenia and bipolar disorder patients, finding age overestimation in both groups compared to controls.

The paper shows increased microglial synapse elimination in schizophrenia patient models and links it to genetic variants and potential therapeutic interventions.