Author
Koch Institute for Integrative Cancer Research At MITORCID 0000-0002-6757-7504Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Blake E. Smith, Lindsey M. Draper, Andrea Garmilla…·Stephanie K. Dougan
This paper develops 4-1BB-targeting lentiviral vectors to selectively expand and transduce antigen-specific T cells, enhancing their function in cancer immunotherapy.
Stephanie A. Gaglione, Rachit S Mukkamala, Chirag Krishna…·Michael E. Birnbaum
The paper introduces a scalable TCR synthesis and screening method, TCRAFT, to map antigen reactivity in vitiligo and pancreatic ductal adenocarcinoma.
Ellen J.K. Xu, Blake E. Smith, Winiffer D. Conce Alberto…·Michael E. Birnbaum
This study develops pMHC-targeted retroviruses for in vivo gene delivery to tumor-specific T cells, enhancing their expansion and anti-tumor activity in mouse models.
Lauren Duhamel, Yiming J. Zhang, William Pinney…·Karl Dane Wittrup
This study shows that CD45 sequestration lowers T cell activation thresholds and enhances anti-tumor immunity when combined with IL-12 therapy in mouse models.