Connor S. Dobson

This paper develops 4-1BB-targeting lentiviral vectors to selectively expand and transduce antigen-specific T cells, enhancing their function in cancer immunotherapy.

The paper introduces a scalable TCR synthesis and screening method, TCRAFT, to map antigen reactivity in vitiligo and pancreatic ductal adenocarcinoma.

This paper develops ARCADE, a high-throughput assay to profile antiviral antibody responses, showing mRNA vaccines elicit broader and stronger responses than adenovirus vector vaccines.

This study develops pMHC-targeted retroviruses for in vivo gene delivery to tumor-specific T cells, enhancing their expansion and anti-tumor activity in mouse models.

The paper introduces VelociRAPTR, a method to map TCR-antigen interactions by combining yeast-displayed TCR libraries with pMHC-displaying virus-like particles, revealing biased recognition patterns and enabling TCR engineering.