Sarah Szvetecz

MSstatsResponse improves detection of drug-protein interactions in chemoproteomics by using a semi-parametric statistical model that avoids fixed curve shapes, enhancing accuracy and robustness in low-replicate and low-dose settings.

This paper optimizes and benchmarks synchro-PASEF for phosphoproteomics, showing improved identification and quantification with retention time summation, and comparable performance to dia-PASEF in modeling phosphosignaling.