Joel D. Federspiel

MSstatsResponse: Semi-parametric statistical model enhances detection of drug-protein interactions in chemoproteomics experiments

MSstatsResponse improves detection of drug-protein interactions in chemoproteomics by using a semi-parametric statistical model that avoids fixed curve shapes, enhancing accuracy and robustness in low-replicate and low-dose settings.

The axonal sorting activity of pseudorabies virus Us9 protein depends on the state of neuronal maturation

This study shows that the Us9 protein of pseudorabies virus regulates axonal sorting differently in immature versus mature neurons, with immature neurons showing reduced Us9-dependent sorting and increased Us9-independent transport.

Cardiac Sex Differences are Established Prior to Gonad Formation

The paper identifies sex-specific transcriptomes and proteomes in cardiac tissue, showing that sex differences are established before gonad formation through post-transcriptional mechanisms and hormonal/sex chromosomal factors.

Changes in mRNA abundance drive differential shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

The paper shows that changes in mRNA decay alter RNA binding protein localization, linking cytoplasmic RNA degradation to transcription.