Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseases
Mitchell W. Pesesky, Ramit Bharanikumar, Lionel Le Bourhis, Hesham ElAbd, Elisa Rosati, Cara L. Carty, Namita Singh, Bernd Bokemeyer, Stefan Schreiber, Siegfried Görg, Marco Garcia Noceda, Paidamoyo Chapfuwa, Rachel M. Gittelman, Damon May, Jennifer N. Dines, , Matthieu Allez
The paper identifies public TCRB sequences expanded in CD or UC, associated with HLA alleles and antigen-specific immune responses, showing differential expansion in CD compared to UC and healthy controls.
Journal of Crohn s and Colitis · Mar 13, 2025Peer-reviewedImmunology