Author

Thomas W. Sedlak

Johns Hopkins UniversityORCID 0000-0002-6791-9105Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Assay:imaging· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Akira SawaiD· 5 shared Gerald NestadtiD· 4 shared Jennifer Marie CoughliniD· 4 shared Andreia Vasconcellos FariaiD· 3 shared Kun YangiD· 3 shared Marina M. MihaljeviciD· 3 shared Nicola G. CascellaiD· 3 shared Zui C. NaritaiD· 3 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersNeuroscience

Akira SawaORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Neuroimaging alterations and relapse in early-stage psychosis

Marina M. Mihaljevic, Anisha Nagpal, Semra Etyemez, Zui C. Narita, Anna Ross, Rebecca Schaub, Nicola G. Cascella, Jennifer Marie Coughlin, Gerald Nestadt, Frederik C. Nucifora, Thomas W. Sedlak, Koko Ishizuka, Vince D. Calhoun, Andreia Vasconcellos Faria, Kun Yang, Akira Sawa

The paper identifies neuroimaging alterations associated with relapse in early-stage psychosis by analyzing resting-state functional connectivity in a cross-sectional study.

Journal of Psychiatry and Neuroscience · Apr 3, 2024Peer-reviewedNeuroscience

Longitudinal changes in brain metabolites in healthy subjects and patients with first episode psychosis (FEP): a 7-Tesla MRS study

Min Wang, Peter B. Barker, Nicola G. Cascella, Jennifer Marie Coughlin, Gerald Nestadt, Frederick Charles Nucifora, Thomas W. Sedlak, Alexandra Kelly, Laurent Younes B, Donald Geman, Lena K. Palaniyappan, Akira Sawa, Kun Yang

This study uses 7-Tesla MRS to track longitudinal changes in brain metabolites in FEP patients and healthy controls, identifying potential trait and state markers for psychosis.

Molecular Psychiatry · Feb 2, 2023Peer-reviewedNeuroscience

Face processing of social cognition in patients with first episode psychosis: Its deficits and association with the right subcallosal anterior cingulate cortex

Zui C. Narita, Kun Yang, Hironori Kuga, Peeraya Piancharoen, Semra Etyemez, Andreia Vasconcellos Faria, Marina M. Mihaljevic, Luisa Longo, Ho Namkung, Jennifer Marie Coughlin, Gerald Nestadt, Frederik C. Nucifora, Thomas W. Sedlak, Rebecca Schaub, Jeff Crawford, , Akira Sawa

This study examines face processing deficits in first episode psychosis patients and links them to reduced resting-state functional connectivity and volume in the right subcallosal anterior cingulate cortex.

Schizophrenia Research · Oct 13, 2021Peer-reviewedNeuroscience

A multimodal study of a first episode psychosis cohort: potential markers of antipsychotic treatment resistance

Kun Yang, Luisa Longo, Zui C. Narita, Nicola G. Cascella, Frederick Charles Nucifora, Jennifer Marie Coughlin, Gerald Nestadt, Thomas W. Sedlak, Marina M. Mihaljevic, Min Wang, Anshel Kenkare, Anisha Nagpal, Mehk Sethi, Alexandra Kelly, Pasquale Di Carlo, , Akira Sawa

The paper identifies potential biomarkers for antipsychotic treatment resistance in first episode psychosis using multimodal data from 138 patients.

Molecular Psychiatry · Oct 12, 2021Peer-reviewedNeuroscience

The glutathione cycle shapes synaptic glutamate activity

Thomas W. Sedlak, Bindu Diana Paul, Gregory Parker, Lynda D. Hester, Adele M. Snowman, Yu Taniguchi, Atsushi Kamiya, Solomon H. Snyder, Akira Sawa

The paper investigates the role of the glutathione cycle in regulating synaptic glutamate levels and excitatory neurotransmission, finding that glutathione acts as a reservoir for glutamate.

Proceedings of the National Academy of Sciences · Jan 28, 2019Peer-reviewedNeuroscience