Koko Ishizuka

Olfactory neuroepithelium biomarker platform: a proof from Alzheimer's disease

The paper demonstrates a non-invasive nasal swab platform with single-cell Western blotting for Alzheimer's disease biomarker detection, showing superior diagnostic performance compared to blood-based methods.

Adolescent prodromal phenotypes of psychiatric disorders: insights from a novel DISC1-perturbed monkey model

This paper presents a novel monkey model with impaired DISC1 gene to study adolescent prodromal phenotypes of psychiatric disorders, finding altered social behavior and disrupted brain connectivity.

The anterior insular cortex mediates higher-order threat learning and memory

This study identifies the role of anterior insular cortex neurons in higher-order threat learning and memory, showing they are essential for temporally separated or diffuse threat contexts but constrain fear expression during retrieval.

Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy

This study shows that astrocyte redox imbalance causes neuronal hypoactivity and affective behaviors in epilepsy, distinct from seizure mechanisms.

Nuclear GAPDH cascade mediates stress-dependent pathological cardiac growth

This study identifies nuclear GAPDH translocation as a mediator of stress-induced cardiac hypertrophy through BRG1-associated chromatin remodeling in mice and human patients.

DISC1-PML protein interaction for congenital CMV infection-induced cortical neural progenitor deficit: perturbance of host signaling via viral IE1

This study identifies the role of CMV viral protein IE1 in disrupting host DISC1-PML interaction, leading to neural progenitor deficits in congenital CMV infection.

Attenuated CaV1.2-BK channel protein interaction in bipolar disorder

The paper identifies attenuated CaV1.2-BK channel protein interaction in bipolar disorder patients and shows its role in intracellular calcium dynamics and cycling behavior.

Neuroimaging alterations and relapse in early-stage psychosis

The paper identifies neuroimaging alterations associated with relapse in early-stage psychosis by analyzing resting-state functional connectivity in a cross-sectional study.

Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders

This study investigates how inflammation in the olfactory epithelium affects the olfactory bulb in schizophrenia and related disorders, finding correlations between immune-related gene expression and OB volume reduction.

Frequency modulation increases the specificity of time-resolved connectivity: A resting-state fMRI study

This study introduces SSB+SWPC, a method that improves time-resolved functional connectivity analysis by reducing high-pass filtering effects, showing better performance in both simulated and real fMRI data.

The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder

This study identifies the miR-124-AMPAR pathway as a common mediator linking polygenic risks to shared behavioral changes in schizophrenia and bipolar disorder.

Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science

This study characterizes olfactory neuronal cells from nasal biopsies using single-cell and bulk RNA sequencing, showing their neuronal similarity and utility in brain disorder research.

Nuclear GAPDH in cortical microglia mediates stress-induced cognitive inflexibility

This study identifies the nuclear GAPDH cascade in microglia as a mediator of stress-induced cognitive inflexibility and shows that targeting it can normalize cognitive deficits.

Pivotal role of Disrupted-in-Schizophrenia 1 (DISC1) in cardiac resilience to ischemic stress

This study identifies DISC1 as a key molecule for cardiomyocyte resilience after myocardial infarction, showing its role in cardioprotection through interaction with GSK3β and its relevance in cardiac health following coronary artery bypass grafting.

Face processing of social cognition in patients with first episode psychosis: Its deficits and association with the right subcallosal anterior cingulate cortex

This study examines face processing deficits in first episode psychosis patients and links them to reduced resting-state functional connectivity and volume in the right subcallosal anterior cingulate cortex.

Volumetric alteration of olfactory bulb and immune-related molecular changes in olfactory epithelium in first episode psychosis patients

This study finds reduced olfactory bulb volume and immune-related molecular changes in olfactory epithelium of first episode psychosis patients, linking nasal factors to brain structural changes.

The cortico-striatal circuit regulates sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport

This study shows that the cortico-striatal circuit regulates sensorimotor gating through Disc1/Huntingtin-mediated Bdnf transport, with lithium restoring deficits in Disc1-LI mice.