Claire S. Simon

This study shows basement membrane mechanics regulate the spatial response to BMP4 in hPSCs and mouse embryos, disrupting gastrulation patterning when mechanics are altered.

The paper shows that inhibiting ERK signaling expands epiblast cells capable of becoming naive pluripotent stem cells in humans, while FGF stimulation expands hypoblast markers.

This study shows that ETV4 and ETV5 regulate lineage specification and embryo patterning in mice by affecting primitive endoderm formation and pluripotency exit.

The paper evaluates gene regulatory network prediction methods in early human embryos, finding that MICA, combining mutual information with chromatin accessibility, provides more reproducible and biologically meaningful results.

This study shows that human blastoids and pluripotent stem cells can enter a dormant state via mTOR inhibition, with distinct temporal dynamics compared to mice.

The paper investigates the conservation of Hippo signaling in the first lineage specification event across four mammalian species, finding that inhibiting the Hippo pathway drives ectopic trophectoderm initiation in all species.

The paper maps the developmental trajectories of endoderm cells in the mouse embryo to reveal lineage relationships and spatial organization during gut formation.