Sarah Hélène Merkling

This study uses metabolomics and gene expression to show the methionine cycle regulates Aedes aegypti development and dengue virus susceptibility, with larval stages showing high methylation capacity and adult stages showing gene expression peaks.

This study identifies a cytochrome P450 gene variant that influences dengue virus susceptibility in Aedes aegypti mosquitoes.

This study challenges the assumed antiviral role of Vago genes in Aedes aegypti by showing that VLG-1 has a modest proviral effect during DENV and ZIKV infections.

This study maps the single-cell transcriptional and metabolic changes in Aedes aegypti midgut and fat body after a bloodmeal, revealing diverse cell populations and a novel fat body-yolk cell type.

This study creates a single-cell atlas of Culex tarsalis midgut cells during West Nile virus infection, revealing cell-type-specific differences in viral replication and immune responses.

The study investigates the role of the siRNA pathway in regulating transposable element expression in Aedes aegypti, finding limited impact in both somatic and gonadal tissues.

The paper identifies environmental and genetic factors influencing population differences in SARS-CoV-2 immune responses using single-cell RNA-sequencing data.