Author

James R. Occean

National Institutes of HealthORCID 0000-0002-6823-6381Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Chang‐Yi CuiiD· 2 shared Changyou Shi· 2 shared Jinshui FaniD· 2 shared Lin WangiD· 2 shared Payel SeniD· 2 shared Simone SidoliiD· 2 shared Supriyo DeiD· 2 shared Agaz Hussain WaniiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

Chang‐Yi CuiORCID

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3 papers

Recent·Most cited

GenomicsNature CommunicationsPeer-reviewedJul 28, 2024

Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging

James R. Occean, Na Yang, Yan Sun…·Payel Sen

This study shows that DNA hydroxymethylation in gene bodies limits transcriptional changes with age in mouse and human tissues.

27 citationstop 5%

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GenomicsMolecular CellPeer-reviewedApr 27, 2023

A hyper-quiescent chromatin state formed during aging is reversed by regeneration

Na Yang, James R. Occean, Daniël P. Melters…·Payel Sen

The paper identifies an aging-associated chromatin state in mice and shows that liver regeneration reverses it.

67 citationstop 2%

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Genetic & Genomic MedicinePsychiatry ResearchPeer-reviewedMay 1, 2022

DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder

James R. Occean, Agaz Hussain Wani, Janelle Donglasan…·Monica Uddin

The paper examines how DNA methylation at NFATC1 CpG sites mediates the relationship between different trauma types and PTSD risk in a prospective study.

6 citations

humanDNA methylation

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