Author

Changyou Shi

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Chang‐Yi CuiiD· 3 shared Jinshui FaniD· 3 shared Payel SeniD· 3 shared Supriyo DeiD· 3 shared Carlos AnerillasiD· 2 shared James R. OcceaniD· 2 shared Lin WangiD· 2 shared Rachel B. MunkiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Chang‐Yi CuiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Reduced LANCL1-AS1 in old human skeletal muscle diminishes mitochondrial activity, shortens mt-mRNA poly(A) tails, and suppresses myogenesis

Jen‐Hao Yang, Elizabeth K. Izydore, Krystyna Mazan-Mamczarz, Dimitrios Tsitsipatis, Julie A. Mattison, Brigette Romero, Changyou Shi, Xiaoling Yang, Rachel B. Munk, Jennifer L. Martindale, Carlos Anerillas, Martín Salamini-Montemurri, Martina Rossi, Yulan Piao, Jinshui Fan, , Myriam Gorospe

The paper identifies LANCL1-AS1 as a lncRNA that declines with age in human skeletal muscle, reduces mitochondrial activity, and impairs myogenesis by shortening mt-mRNA poly(A) tails.

bioRxiv · Jul 6, 2026 · PreprintMolecular Biology

Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging

James R. Occean, Na Yang, Yan Sun, Marshall S. Dawkins, Rachel B. Munk, Cédric Belair, Showkat Ahmad Dar, Carlos Anerillas, Lin Wang, Changyou Shi, Christopher Dunn, Michel Bernier, Nathan L. Price, Julie S. Kim, Chang‐Yi Cui, , Payel Sen

This study shows that DNA hydroxymethylation in gene bodies limits transcriptional changes with age in mouse and human tissues.

Nature Communications · Jul 28, 2024Peer-reviewedGenomics

A hyper-quiescent chromatin state formed during aging is reversed by regeneration

Na Yang, James R. Occean, Daniël P. Melters, Changyou Shi, Lin Wang, Stephanie Stransky, Maı̀re E. Doyle, Chang‐Yi Cui, Michael R. Delannoy, Jinshui Fan, Eliza M. Slama, Josephine Mary Egan, Supriyo De, Steven Clark Cunningham, Rafael de Cabo, , Payel Sen

The paper identifies an aging-associated chromatin state in mice and shows that liver regeneration reverses it.

Molecular Cell · Apr 27, 2023Peer-reviewedGenomics