Daniël P. Melters

This study shows that H2B variants, particularly H2B1O, alter chromatin accessibility and induce EMT in breast cancer, suggesting their role as onco-histones and potential therapeutic targets.

This study shows H1.5 interacts with CENP-A nucleosomes at centromeres, and its depletion causes centromere dysfunction and mitotic defects in human cells.

This study shows that H2B variants alter chromatin structure and oncogenic gene expression, suggesting they may be early cancer biomarkers and therapeutic targets.

The paper identifies an aging-associated chromatin state in mice and shows that liver regeneration reverses it.