Radiation therapy synergizes with mRNA vaccination to overcome microglia-mediated suppression of dendritic cell migration and T cell priming in glioblastoma
Amy J. Wisdom, Zachary J. Rogers, Fiona Chatterjee…·Stefani Spranger
Author
Salk Institute for Biological StudiesORCID 0000-0002-6837-0134Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Amy J. Wisdom, Zachary J. Rogers, Fiona Chatterjee…·Stefani Spranger
Jasper Hsu, Hyemin Song, Satoshi Ogawa…·Dannielle D. Engle
This study identifies CA19-9's role in remodeling the PDAC tumor microenvironment by inducing IL1a and TGFb, leading to immunosuppressive changes that can be mitigated by blocking these factors.
Ian Magill, Val Piekarsa, Σοφία Κοσσίδα…·Xutong Gong
The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.
Abigail A. Jaquish, Eleni Phung, Xutong Gong…·Deepshika Ramanan
The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.