BiophysicsbioRxivPreprint
Who's driving? Common evolutionary mechanism of activation of class A GPCRs
Antoni Marciniak, Paweł Kozielewicz, Darko Mitrovic, Lucie Delemotte
The paper identifies a common evolutionary mechanism for class A GPCR activation using coevolution and machine learning, validated through molecular dynamics simulations and ligand effect modeling.
DOI 10.64898/2026.06.25.734477