Sandra Acosta

This study shows that MIF overexpression after SARS-CoV-2 infection promotes neural regeneration in human brain organoids through EGFR signaling and self-upregulation.

The paper develops ImPheNet, a deep learning tool to classify phenotypes and assess drug toxicity in Dravet Syndrome brain organoids using live imaging data.

The paper introduces CBM KG, a knowledge graph linking COVID-19 and neurodegenerative diseases through causal mechanisms, integrating 2,800 relationships from 63 studies.

This study enhances homology-directed repair (HDR) efficiency by using PRDM9-Cas9 fusion with CtIP, validated through reporter systems for small and longer edits.

The paper shows that tissue-specific enhancers are mostly intronic and regulate genes involved in tissue-specific functions, while housekeeping genes are controlled by intergenic enhancers.

This paper identifies amino acid changes and genes associated with longevity across mammals, showing their potential to improve human lifespan heritability interpretation.

The paper identifies a human accelerated region in Chromosome 14q12 that enhances forebrain expansion through increased enhancer activity in transgenic mice and organoids.