Functional Role of Small Extrachromosomal Circular DNA in Colorectal Cancer
Judith Mary Hariprakash, Egija Zole, Weijia Feng, Dan Hao, Lasse Bøllehuus Hansen, Nirmalya Bandyopadhyay, Marghoob Mohiyuddin, Sihan Wu, Astrid Zedlitz Johansen, Julia Sidenius Johansen, Birgitte Regenberg
This study investigates the role of small extrachromosomal circular DNA (eccDNA) in colorectal cancer, finding that it contributes to gene expression, immune cell recruitment, and poor patient outcomes.
bioRxiv · Aug 1, 2025 · PreprintCancer Biology