Author

Benjamin E. Clarke

National University of SingaporeORCID 0000-0001-5775-352XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Rickie PataniiD· 2 shared Aaron Z. WageniD· 1 shared Ali E. GhareebiD· 1 shared Christina E. ToomeyiD· 1 shared Clare Elizabeth BryantiD· 1 shared David KlenermaniD· 1 shared Dilan S. AthaudaiD· 1 shared Dmitri A. RusakoviD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Rickie PataniORCID

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2 papers

Recent·Most cited

Toxicity of MAPT 4R RNA Contributes to Motor Neuron Degeneration in ALS

Hamish Crerar, Michele Stasi, Koustav Pal, Sabrina Pia Nuccio, Marija Petrić, Giulia Manferrari, Yiran Wang, Benjamin E. Clarke, Marc‐David Ruepp, Marco Di Antonio, Rickie Patani

The paper shows that increased 4R Tau RNA contributes to motor neuron degeneration in ALS by reducing viability and that targeting this RNA could be therapeutic.

bioRxiv · Sep 29, 2026 · PreprintNeuroscience

Astrocytic RNA editing regulates the host immune response to alpha-synuclein

Karishma D’Sa, Minee L. Choi, Aaron Z. Wagen, Núria Setó‐Salvia, Olga Kopach, James R. Evans, Margarida Rodrigues, Patricia Lopez-Garcia, Joanne Lachica, Benjamin E. Clarke, Jaijeet Singh, Ali E. Ghareeb, James Bayne, Melissa Grant‐Peters, Sonia García-Ruiz, , Mina Ryten

The paper shows that astrocytic RNA editing via ADAR1 modulates immune responses to alpha-synuclein, contributing to neuroinflammation in Parkinson's disease.

Science Advances · Apr 11, 2025Peer-reviewedNeuroscience