Author

Amaury Leruste

InsermORCID 0000-0002-6891-9588Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Joshua J. WaterfalliD· 2 shared Ana Inés LalanneiD· 1 shared Aurélie DarboisiD· 1 shared Camille JametiD· 1 shared Céline Collin· 1 shared Christine SedlikiD· 1 shared Eliane PiaggioiD· 1 shared Federico MarzialiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Joshua J. WaterfallORCID

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2 papers

Recent·Most cited

Specific killing of Ewing sarcoma by TCR-T cells targeting public neogene-encoded antigens

Ana Inés Lalanne, Céline Collin, Floriane Petit, Mégane Lacaud, Yago A. Arribas, Aurélie Darbois, Amaury Leruste, Maria K. Koshkina, Kyle A. Raymond, Paul Klein, Julien Vibert, Sakina Zaïdi, Sandrine Grossetête, Jill Pilet, Karine Laud-Duval, , Olivier Delattre

The paper demonstrates that TCR-T cells targeting neogene-encoded antigens can specifically kill Ewing sarcoma cells in vitro and in vivo.

bioRxiv · Jun 25, 2026 · PreprintImmunology

Myeloid reprogramming by poly(I:C) recruits progenitor-exhausted CD8+ T cells and sensitizes rhabdoid tumors to PD-1 blockade

Valeria Sandoval Manríquez, Sofia Cavada-Silva, Kévin Beccaria, Leticia Laura Niborski, Amaury Leruste, Wilfrid Richer, Mathias Vandenbogaert, Zhi‐Yan Han, Christine Sedlik, Jordan Denizeau, Jérémy Mesple, Zoé Fusilier, Laëtitia Lesage, Jérémie D. Goldstein, Yohan Gerber-Ferder, , Eliane Piaggio

This study shows that poly(I:C) reprograms myeloid cells in rhabdoid tumors, enhancing CD8+ T cell infiltration and improving response to PD-1 blockade.

bioRxiv · Dec 29, 2025 · PreprintImmunology