Author

Jason M. Link

Oregon Health & Science UniversityORCID 0000-0002-6892-0431Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:scATAC-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Rosalie C. SearsiD· 3 shared Andrew AdeyiD· 2 shared Carl PelziD· 2 shared Colin J. DanieliD· 2 shared Ethan S. AgritelleyiD· 2 shared Jennifer R. EngiD· 2 shared Motoyuki TsudaiD· 2 shared Patrick Joseph WorthiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

Rosalie C. SearsORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 29, 2026

Epigenetic progression of pancreatic cancer to aggressive subtypes involves alternate routes of lineage reprogramming in subtype-intermediate progenitor cells

Kevin Hawthorne, Jennifer R. Eng, Motoyuki Tsuda…·Rosalie C. Sears

The paper identifies subtype-intermediate progenitor cells in pancreatic cancer with distinct epigenetic profiles linked to clinical outcomes and lineage reprogramming.

DOI 10.64898/2026.09.28.754674

humanscATAC-seq

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Cancer BiologybioRxivPreprintDec 15, 2025

A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway

Motoyuki Tsuda, Dove J. Keith, Colin J. Daniel…·Rosalie C. Sears

The paper identifies resistance mechanisms to KRAS-MEK pathway targeting in PDAC by analyzing clinical trial data and multi-omics profiles, showing that KRAS/MYC co-gain correlates with resistance and that co-targeting these genes is synergistic.

DOI 10.64898/2025.12.12.693851

humanbulk RNA-seq

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GeneticsNature BiotechnologyPeer-reviewedJul 5, 2021

High-content single-cell combinatorial indexing

Ryan M. Mulqueen, Dmitry Pokholok, Brendan L. O’Connell…·Andrew Adey

This paper introduces a novel adaptor-switching strategy, s3, that significantly improves usable reads per cell in single-cell genomics assays while maintaining high-throughput capabilities.

98 citationstop 2%

mousehuman

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