Author

Katsuhiko Mitachi

University of Tennessee Health Science CenterORCID 0000-0002-6897-8959Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Jacob M. KirshiD· 2 shared Michio KurosuiD· 2 shared William ClemonsiD· 2 shared Antonio Sánchez‐RuiziD· 1 shared David MingleiD· 1 shared Francisco SarabiaiD· 1 shared Iván Cheng‐SáncheziD· 1 shared Jessica M. OchoaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Jacob M. KirshORCID

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2 papers

Recent·Most cited

Rationally Engineered, Chemically Stable Tunicamycin Analogues Decouple DPAGT1 Inhibition from Non-Selective Toxicity

Katsuhiko Mitachi, Antonio Sánchez‐Ruiz, David Mingle, Iván Cheng‐Sánchez, Jacob M. Kirsh, Francisco Sarabia, William Clemons, Michio Kurosu

This paper develops chemically stable tunicamycin analogues that inhibit DPAGT1 selectively with reduced toxicity and improved pharmacokinetics.

bioRxiv · Jul 29, 2026 · PreprintBiochemistry

Structures of bacterial and human phosphoglycosyltransferases bound to a common inhibitor inform selective therapeutics

Yusrah B. Kaudeer, Jacob M. Kirsh, Katsuhiko Mitachi, Jessica M. Ochoa, Marie-Therese Soroush-Pejrimovsky, Yancheng E. Li, Vy N. Nguyen, Michio Kurosu, William Clemons

The paper determines cryo-EM structures of APPB bound to MraY and DPAGT1, revealing conformational differences that guide the design of selective therapeutics for antibacterial and anticancer applications.

ACS Chemical Biology · Mar 17, 2026Peer-reviewedBiochemistry