Author

Jacob M. Kirsh

California Institute of TechnologyORCID 0000-0002-1444-2913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Organism:bacteria (other)· 1 Assay:cryo-EM· 1 Organism:E. coli· 1 Assay:imaging· 1

Frequent Co-Authors

Katsuhiko MitachiiD· 2 shared Michio KurosuiD· 2 shared William ClemonsiD· 2 shared Antonio Sánchez‐RuiziD· 1 shared David MingleiD· 1 shared Francisco SarabiaiD· 1 shared Irimpan I. MathewsiD· 1 shared Iván Cheng‐SáncheziD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Katsuhiko MitachiORCID

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Author profile →

3 papers

Recent·Most cited

Rationally Engineered, Chemically Stable Tunicamycin Analogues Decouple DPAGT1 Inhibition from Non-Selective Toxicity

Katsuhiko Mitachi, Antonio Sánchez‐Ruiz, David Mingle, Iván Cheng‐Sánchez, Jacob M. Kirsh, Francisco Sarabia, William Clemons, Michio Kurosu

This paper develops chemically stable tunicamycin analogues that inhibit DPAGT1 selectively with reduced toxicity and improved pharmacokinetics.

bioRxiv · Jul 29, 2026 · PreprintBiochemistry

Structures of bacterial and human phosphoglycosyltransferases bound to a common inhibitor inform selective therapeutics

Yusrah B. Kaudeer, Jacob M. Kirsh, Katsuhiko Mitachi, Jessica M. Ochoa, Marie-Therese Soroush-Pejrimovsky, Yancheng E. Li, Vy N. Nguyen, Michio Kurosu, William Clemons

The paper determines cryo-EM structures of APPB bound to MraY and DPAGT1, revealing conformational differences that guide the design of selective therapeutics for antibacterial and anticancer applications.

ACS Chemical Biology · Mar 17, 2026Peer-reviewedBiochemistry

Covalent Drug binding in Live Cells Monitored by Mid-IR Quantum Cascade Laser Spectroscopy: Photoactive Yellow Protein as a Model System

Srijit Mukherjee, Steven D.E. Fried, Nathalie Y. Hong, Nahal Bagheri, Jacek Kozuch, Irimpan I. Mathews, Jacob M. Kirsh, Steven G. Boxer

This paper develops a mid-IR quantum cascade laser spectroscopy method to detect drug-target interactions in live cells using photoactive yellow protein as a model system.

bioRxiv · Aug 15, 2025 · PreprintBiophysics