Structures of bacterial and human phosphoglycosyltransferases bound to a common inhibitor inform selective therapeutics
Yusrah B. Kaudeer, Jacob M. Kirsh, Katsuhiko Mitachi, Jessica M. Ochoa, Marie-Therese Soroush-Pejrimovsky, Yancheng E. Li, Vy N. Nguyen, Michio Kurosu, William Clemons
The paper determines cryo-EM structures of APPB bound to MraY and DPAGT1, revealing conformational differences that guide the design of selective therapeutics for antibacterial and anticancer applications.
ACS Chemical Biology · Mar 17, 2026Peer-reviewedBiochemistry