BiochemistryACS Chemical BiologyPeer-reviewed
Structures of bacterial and human phosphoglycosyltransferases bound to a common inhibitor inform selective therapeutics
Yusrah B. Kaudeer, Jacob M. Kirsh, Katsuhiko Mitachi…·William Clemons
The paper determines cryo-EM structures of APPB bound to MraY and DPAGT1, revealing conformational differences that guide the design of selective therapeutics for antibacterial and anticancer applications.
DOI 10.1021/acschembio.5c01037