Charlotte M. Fischer

Biomolecular condensates sustain pH gradients at equilibrium driven by charge neutralisation

This study shows that biomolecular condensates can sustain pH gradients without energy input by neutralizing charges, revealing their role in creating pH microenvironments.

Diffusing protein binders to intrinsically disordered proteins

The paper develops RFdiffusion to generate protein binders for IDPs/IDRs, achieving nanomolar affinity and functional applications in amylin and IL2RG.

Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen

The paper investigates thyroglobulin phase separation in thyroid follicles, showing it forms storage depots and reveals a mechanism for hormone homeostasis.

Temperature-induced changes in protein interactions control RNA recruitment to G3BP1 condensates

The paper investigates how temperature affects G3BP1-RNA phase separation, revealing that while the phase boundary remains stable, stoichiometry and energetics shift, driven by entropic processes.