Author

Tharaka Darshana Wijerathne

Western University of Health SciencesORCID 0000-0002-6900-3272Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Assay:electrophysiology· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aashish BhattiD· 3 shared Jérôme J. LacroixiD· 3 shared Yun LuoiD· 3 shared Wenjuan JiangiD· 2 shared Aneesh ChandrasekharaniD· 1 shared Shu LiiD· 1 shared Wei HaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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3 shared papersBiophysics

Aashish BhattORCID

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3 papers

Recent·Most cited

Yoda molecules agonize PIEZO2

Tharaka Darshana Wijerathne, Aneesh Chandrasekharan, Aashish Bhatt, Yun Luo, Jérôme J. Lacroix

This study shows Yoda1 agonizes PIEZO2 with efficacy similar to PIEZO1 but distinct effects on calcium influx and inactivation kinetics.

bioRxiv · Oct 13, 2026 · PreprintBiophysics

A two-step clockwork mechanism opens a proteo-lipidic pore in PIEZO2 channels

Shu Li, Tharaka Darshana Wijerathne, Aashish Bhatt, Wenjuan Jiang, Jérôme J. Lacroix, Wei Han, Yun Luo

This study reveals how tension-induced structural changes in PIEZO2 channels lead to pore opening and ion conduction through dynamic conformational motions.

bioRxiv · Feb 10, 2025 · PreprintBiophysics

Mammalian PIEZO channels rectify anionic currents

Tharaka Darshana Wijerathne, Aashish Bhatt, Wenjuan Jiang, Yun Luo, Jérôme J. Lacroix

This study shows that mammalian PIEZO1 and PIEZO2 channels rectify chloride currents inwardly, while sodium currents show little rectification, indicating voltage-dependent anion permeation.

Biophysical Journal · Nov 14, 2024Peer-reviewedBiophysics