Jérôme J. Lacroix

This study shows Yoda1 agonizes PIEZO2 with efficacy similar to PIEZO1 but distinct effects on calcium influx and inactivation kinetics.

This study reveals how tension-induced structural changes in PIEZO2 channels lead to pore opening and ion conduction through dynamic conformational motions.

This study uses molecular dynamics simulations to quantify how voltage-dependent free energy barriers in ion-nanopore systems lead to current rectification, showing it depends on ion type and pore polarity.

This study shows that mammalian PIEZO1 and PIEZO2 channels rectify chloride currents inwardly, while sodium currents show little rectification, indicating voltage-dependent anion permeation.

This study uses HaloTag technology to visualize PIEZO1 localization and activity in hiPSC-derived cells and organoids, enabling mechanotransduction studies with high temporal resolution.

This study identifies the mechanism by which focused ultrasound excites neurons through mechanosensitive calcium channels and ion channel amplification.