Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination
Jea Kwon, Sunpil Kim, Junsung Woo, Keiko Tanaka, Oliver James, Erik De Schutter, Sungho Hong, C. Justin Lee
The paper shows that astrocytic Best1 mediates a switch in tonic inhibition in cerebellar granule cells during adolescence, enhancing motor coordination through network-level changes.
Experimental & Molecular Medicine · Feb 18, 2026Peer-reviewedNeuroscience