Chris I. De Zeeuw

The paper investigates the electrophysiological properties of mesodiencephalic junction neurons projecting to the inferior olive and finds they exhibit distinct firing patterns and response characteristics compared to non-projecting neurons.

The paper reveals that neocerebellar modules contain both open- and closed-loop microcomplexes, allowing for differential use of mossy fiber information in feedforward control and feedback regulation.

The paper shows that Purkinje cells in Crus I/II encode visual stimuli and impending choices during learning of a visuomotor task, with increased selectivity over time.

The paper investigates tactile-motion perception deficits in Parkinson's disease by analyzing functional MRI connectivity and finds altered sensorimotor network organization associated with impaired perception.

The paper develops a computational model of olivocerebellar modules to study synaptic plasticity dynamics and shows how IO neuron oscillations and coupling regulate plasticity in Upbound and Downbound micromodules.

This study shows that ATXN2 polyglutamine expansion impairs QKI-dependent alternative splicing and oligodendrocyte maintenance in a mouse model of SCA2.

The paper identifies a cortico-cerebellar pathway that modulates ipsilateral limb movement, showing its role in initiation and coordination without affecting contralateral movement.

This paper demonstrates the feasibility of functional ultrasound imaging (fUSi) for monitoring brain activity during real-world activities like walking over 20 months.

This study investigates how cerebellar Purkinje cells control tongue movements during drinking, showing that complex spikes signal target position changes and simple spikes influence movement direction.

This study examines cerebellar dentate nucleus neuronal activity during a visual attention task in rhesus macaques, revealing dynamic encoding of visual stimuli and task-related behavior.

This study examines neuronal dynamics in the cerebellum and prefrontal cortex during motor timing adaptation, finding differential roles in temporal adaptation between two conditioning paradigms.

The paper introduces a novel behavioral test, MEGIT, to assess social preference in mice and shows it detects differences in social behavior in genetic models of ASD and WBS.

This study shows acute aerobic exercise improves eyeblink conditioning in active individuals but not sedentary ones.

The paper uses mesoscale simulations to show that synergistic plasticity in cerebellar circuits is essential for classical eyeblink conditioning.

This study shows that different Purkinje cell pathologies in mice lead to distinct patterns of progressive gait ataxia, highlighting the importance of pathological mechanisms in disease progression.

This paper investigates the impact of the PDE11A-Y727C variant on neural physiology, showing reduced catalytic activity and altered subcellular compartmentalization without significant effects on eye growth or sleep quality.

This study investigates how synaptic changes in the cerebellar nuclei contribute to associative learning in mice during eyeblink conditioning.

This study investigates how sleep affects cerebellar processing in adult mice by examining correlations between muscle twitches, EEG, and climbing fiber activity during different sleep stages.

This paper develops a long-deletion mouse model of Williams syndrome to study vascular and neural phenotypes, finding that Ncf1 modulates both cardiovascular and neuropsychological symptoms.

The paper shows that nystagmus and oscillating retinal ganglion cells are common features in different mouse models of congenital stationary night blindness.

The paper investigates how inhibitory and excitatory inputs to olivary neurons interact to generate spiking patterns, showing that timing of inputs affects phase and gain of the output.

This study identifies a novel cAMP-EPAC-PKCε-RIM1α signaling cascade that regulates presynaptic long-term potentiation and motor learning in the cerebellum.

The paper investigates how climbing fiber activity in the cerebellum adapts to the saliency of sensory inputs and correlates with action readiness in mice during a go/no-go task.

The paper shows that presynaptic NMDARs in granule cells are essential for bidirectional synaptic plasticity and motor learning in adult rodents.

This study investigates Purkinje cell activity in the medial and lateral cerebellum of rhesus macaques during antisaccade tasks, revealing distinct roles in volitional eye movement suppression.

This study identifies the mesodiencephalic junction as a hub for cerebro-cerebellar communication via both mossy fibre and climbing fibre systems in mice.

This study shows cerebellar Purkinje cells modulate S1-M1 coherence in theta and gamma bands during whisker stimulation, with effects dependent on region and behavior.

This study investigates how Purkinje cell activity in the cerebellum coordinates autonomic and sensorimotor behaviors during respiration, showing context- and phase-dependent effects.

This study shows that perineuronal nets in the deep cerebellar nuclei are involved in regulating cerebellar plasticity and associative memory through structural and functional changes during eyeblink conditioning.

This study investigates how cerebellar and cortical inputs regulate thalamic spiking in mice, revealing mechanisms of temporal coding and adaptation in motor thalamus.