Mario Negrello

Homeostatic bidirectional plasticity in Upbound and Downbound micromodules in a model of the olivocerebellar loop

The paper develops a computational model of olivocerebellar modules to study synaptic plasticity dynamics and shows how IO neuron oscillations and coupling regulate plasticity in Upbound and Downbound micromodules.

How inhibitory and excitatory inputs gate output of the inferior olive

The paper investigates how inhibitory and excitatory inputs to olivary neurons interact to generate spiking patterns, showing that timing of inputs affects phase and gain of the output.

Cerebellar Purkinje cells can differentially modulate coherence between sensory and motor cortex depending on region and behavior

This study shows cerebellar Purkinje cells modulate S1-M1 coherence in theta and gamma bands during whisker stimulation, with effects dependent on region and behavior.

Functional convergence of autonomic and sensorimotor processing in the lateral cerebellum

This study investigates how Purkinje cell activity in the cerebellum coordinates autonomic and sensorimotor behaviors during respiration, showing context- and phase-dependent effects.

NINscope: a versatile miniscope for multi-region circuit investigations

NINscope is an open-source miniscope that enables multi-region neural activity recording and optogenetic stimulation in unrestrained mice, revealing functional connectivity and behavioral correlations.

Quasiperiodic Rhythms of the Inferior Olive

This study investigates how subthreshold oscillations and synaptic inputs shape complex spike timing in the inferior olive of awake mice, revealing semi-periodic activity patterns and resonance properties.

Neurons of the inferior olive respond to broad classes of sensory input while subject to homeostatic control

The paper investigates how inferior olive neurons respond to different sensory inputs and shows their firing is influenced by recent activity history rather than stimulus strength.

Potentiation of cerebellar Purkinje cells facilitates whisker reflex adaptation through increased simple spike activity

This study shows that increased simple spike activity in Purkinje cells, facilitated by long-term potentiation at parallel fiber synapses, contributes to whisker reflex adaptation in mice.