Steven A. Prescott

Spinotrode: long-term intraspinal electrophysiological recordings to unravel dorsal horn neuron dynamics in behaving mice

The paper introduces Spinotrode, a vertebral implant for long-term single-cell recordings in the dorsal horns of behaving mice, revealing new insights into spinal neuron dynamics during natural behaviors.

Adaptation in somatosensory afferents improves rate and temporal coding of vibrotactile stimulus features

The paper shows adaptation in somatosensory afferents improves rate and temporal coding of vibrotactile stimulus features by modulating spiking in different ways.

Homeostatic regulation of neuronal activity: implications and feasibility of compartment-specific feedback

The paper investigates compartment-specific feedback mechanisms in neurons using computational models to show that local calcium signals can encode separate error signals for homeostatic regulation.

Quantifying changes in pain sensitivity using reproducible transcutaneous optogenetic stimulation in behaving mice

This study uses optogenetic stimulation to quantify changes in pain sensitivity in mice, finding that ramped photostimuli are more effective than pulsed stimuli for detecting inflammation and analgesia.

Physiologically realistic gamma activity produced in silico by weakening the PING attractor state

This paper modifies the PING mechanism to produce more realistic gamma oscillations by introducing biophysically motivated changes that reduce synchronization and increase transient activity.

Nociceptor clock genes control excitability and pain perception in a sex- and time-dependent manner

This study shows that clock genes in nociceptors affect pain sensitivity differently in males and females across times of day.

Spinal processing of spatiotemporally diverse tactile stimuli: Implications for allodynia and spinal cord stimulation

The paper models spinal dorsal horn processing of tactile stimuli to explain why certain stimuli cause allodynia and how spinal cord stimulation can alleviate it.

Encoding of vibrotactile stimuli by mechanoreceptors in rodent glabrous skin

This study investigates the coding properties of low-threshold mechanoreceptors in rodent glabrous skin, showing their heterogeneity and how they encode vibrotactile stimuli through rate and temporal coding.

Equivalent excitability through different sodium channels and implications for the analgesic efficacy of selective drugs

The paper shows that nociceptors can achieve equivalent excitability through different sodium channel subtypes, challenging the effectiveness of subtype-selective analgesic drugs.

Impact of extracellular current flow on action potential propagation in myelinated axons

This paper shows that extracellular conditions significantly affect action potential conduction velocity in myelinated axons by influencing axial current flow.

Paresthesia during spinal cord stimulation depends on synchrony of dorsal column axon activation

This study shows that kilohertz-frequency spinal cord stimulation activates dorsal column axons but causes asynchronous spiking, leading to paresthesia-free analgesia.

Minimal requirements for a neuron to co-regulate many properties and the implications for ion channel correlations and robustness

The paper shows that neurons can co-regulate multiple properties only if the number of adjustable ion channels exceeds the number of regulated properties, and that ion channel correlations arise when solution space dimensionality is low.

Multiscale computer model of the spinal dorsal horn reveals changes in network processing associated with chronic pain

The paper develops a computational model of the spinal dorsal horn to study how chronic pain alters neural processing.

Spike initiation properties in the axon support high-fidelity signal transmission

The paper shows that the axon's spike initiation is transient and depends on depolarization rate and KV1 channels, implementing a high-pass filter for high-fidelity signal transmission.

Physiological noise optimizes multiplexed coding of vibrotactile-like signals in somatosensory cortex

The paper shows that physiological noise enhances the ability of somatosensory cortex neurons to multiplex vibrotactile signal features by enabling both rate and temporal coding.

Control iPSC lines with clinically annotated genetic variants for versatile multi-lineage differentiation

The paper describes the generation of genetically annotated iPSC lines from healthy donors and demonstrates their use in creating disease-relevant cell types and identifying variant-preferred lines for control in disease modeling.

Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn

The paper shows excitatory neurons in the spinal dorsal horn are more disinhibited than inhibitory neurons due to chloride dysregulation, despite similar chloride levels, because they rely more on inhibition to balance strong excitation.

A mutation-independent approach via transcriptional upregulation of a disease modifier gene rescues muscular dystrophy in vivo.

This paper demonstrates that upregulating a disease modifier gene using CRISPR/dCas9 can rescue muscular dystrophy in mice, showing that muscle fibrosis may be reversible.