Siegfried Hapfelmeier

Decoupling bile acid 7α-dehydroxylation from colonization resistance to Clostridioides difficile

This study shows that 7-dehydroxylated bile acid production by commensal bacteria is not sufficient for colonization resistance against C. difficile, suggesting other mechanisms are involved.

Component specific responses of the microbiomes to common chemical stressors in the human food chain

This study examines how chemical stressors affect microbiomes across different food chain components, finding component-specific responses and shifts in microbial composition and stability.

Innate immune system signaling and CD11b+CD11c+CD103+ cell migration to the brain underlie changes in mouse behavior after microbial colonization.

This study identifies innate immune signaling and CD11b+CD11c+CD103+ cell migration to the brain as mechanisms linking microbial colonization to behavioral changes in mice.

Microbiota-dependent in vivo biotransformation, accumulation, and excretion of arsenic from arsenobetaine-rich diet

This study shows that gut microbiota in mice transform arsenobetaine into toxic arsenic species, affecting its accumulation and excretion.

Pipeline for species-resolved full-length16S rRNA amplicon nanopore sequencing analysis of low-complexity bacterial microbiota

This paper presents a pipeline for full-length 16S rRNA amplicon nanopore sequencing to analyze low-complexity microbiota, achieving species-level classification more accurately than short-read methods.

The stationary phase-specific sRNA fimR2 is a multifunctional regulator of bacterial motility, biofilm formation and virulence

This paper identifies fimR2 as a stationary phase-specific sRNA in E. coli that regulates biofilm formation, motility, and virulence by modulating CsrA activity and enhancing infectivity.

Production of germ-free mosquitoes via transient colonisation allows stage-specific investigation of host-microbiota interactions

This study develops a method to produce germ-free mosquitoes that can be decolonized at any stage, enabling the study of microbiota effects on larval and adult development without developmental deficits.