Kathy D. McCoy

This study identifies microbiome-derived hydroxyphenyl propanoates (HPPs) that enhance antitumour immunity by boosting gasdermin D activity in myeloid cells, improving immune checkpoint therapy outcomes in mice and correlating with better responses in human melanoma patients.

The paper identifies a novel macrophage-like population in exocrine glands sustained by ILC2-derived GM-CSF, showing conservation across species.

This study identifies Sutterella wadsworthensis as a low-abundant intestinal commensal that suppresses anti-leukemia immune responses in chronic myeloid leukemia.

This study tracks rapid genetic diversification of Bacteroides thetaiotaomicron in mono-associated mice over 28 days, identifying polymorphisms, phase-variable loci, and spatial variation in the gut.

This study identifies innate immune signaling and CD11b+CD11c+CD103+ cell migration to the brain as mechanisms linking microbial colonization to behavioral changes in mice.

This study shows T cells regulate intestinal motility and enteric neuronal responses to microbiota, with distinct roles in ileum and colon.

This study shows that the gut microbiota influences sexual dimorphism in ALS-linked TDP43 mice by affecting disease onset and severity, independent of sex hormones.

The paper identifies a microbial metabolite, indole 3-propionic acid, that can reverse non-remitting EAE in aged mice, suggesting therapeutic potential for progressive MS.