Daniel K. Krizay

The paper develops topological synchrony measures to identify disease-relevant phenotypes in mouse models of epileptic encephalopathies using MEAs.

The paper uses single-cell transcriptomics to analyze ex vivo models of cortical and hippocampal development, identifying region-specific transcriptomic changes and disease-associated gene expression differences.

This paper proposes a transcriptome reversal approach for drug discovery in neurodevelopmental disorders to identify compounds that reverse disease-associated gene-expression signatures.

This study models GRIN2A-related DEE in mice, identifies seizure and behavioral abnormalities, and evaluates treatment strategies.

This study identifies GNB1 mutations causing neurodevelopmental disorder and shows ethosuximide effectively treats symptoms in mouse and cellular models.