Hyperactivity of indirect pathway-projecting spiny projection neurons drives compulsive behavior
Sean C. Piantadosi, Elizabeth E. Manning, Brittany L. Chamberlain, James Hyde, Zoe LaPalombara, Nicholas M. Bannon, Jamie L. Pierson, Vijay Mohan K Namboodiri, Susanne E. Ahmari
The paper identifies indirect pathway-projecting spiny projection neurons as a driver of compulsive behavior in a mouse model and shows that reducing their activity alleviates compulsive grooming.
Nature Communications · May 24, 2024Peer-reviewedNeuroscience