Sean C. Piantadosi

This study identifies the physiological and behavioral conditions that trigger dopamine release from locus coeruleus axons, showing modality-dependent release constraints.

This study investigates the role of endocannabinoids in reward-seeking behavior through thalamo-striatal circuits using in vivo and machine learning methods.

This study investigates the roles of central striatum (CS) and anterior lateral motor area (ALM) in initiating and sustaining naturalistic grooming behavior using fiber photometry and optogenetic stimulation in mice.

This study identifies an insular-claustral opioid circuit that stress modulates to influence hedonic feeding through KOR signaling and prodynorphin-expressing neurons.

The paper identifies indirect pathway-projecting spiny projection neurons as a driver of compulsive behavior in a mouse model and shows that reducing their activity alleviates compulsive grooming.

This paper introduces a microfluidic and fluorescence platform for in vivo neuropharmacology, enabling drug delivery and neural activity monitoring in rodent brains.

This study shows that specific BLA neuronal ensembles control valence-specific behavior, with their activity shifting behavioral responses toward appetitive or aversive actions.

The paper identifies how specific neurons in the medial accumbens shell encode reward preference and show distinct roles in driving reward behavior.

The paper investigates LOFC activity during compulsive grooming and reversal learning in OCD models, finding distinct neural patterns that normalize with fluoxetine treatment.

The paper identifies differentially expressed transcripts in OCD patients' striatum and OFC, showing enrichment for synapse-associated genes and changes in cell type fractions.

This study identifies an endogenous opioid circuit in mice that regulates appetitive behavior through a dorsal raphe to nucleus accumbens projection.

The paper investigates the role of BDNF transcript variants in altered inhibitory circuitry in depression by analyzing gene expression and behavioral changes in humans and mice.