Sahin Naqvi

The paper introduces dubTAGs, small molecules that stabilize proteins tagged with FKBP12F36V by recruiting deubiquitinases, enabling tunable and reversible control of protein levels.

The paper uses 3D craniofacial data and genome-wide association analysis to link craniofacial variation to genetic diversity, evolutionary processes, and clinical conditions in modern humans.

The paper uses transfer learning to predict how TF dosage affects chromatin accessibility, finding that motif affinity and distribution determine sensitivity or buffering of TF concentration changes.

The paper shows how DNA motifs guide transcription factor cooperativity in embryonic face and limb mesenchyme, shaping cell identity and morphology.

This study performs a joint multi-ancestry and admixed GWAS on cranial vault shape, identifying 30 genome-wide significant loci and highlighting genetic pathways involved in craniofacial development.

The paper modulates SOX9 levels in human facial progenitors to study dosage sensitivity and identifies regulatory elements and genes that are sensitive to SOX9 changes.

The paper identifies upstream regulators of immune genes in human T cells and maps their regulatory network, revealing its enrichment for immune disease variants.

GWAS hits (44 UK Biobank traits) and GTEx v8 cis-eQTLs (38 tissues) differ systematically: eQTLs cluster near transcription start sites of weakly constrained genes; GWAS hits favour constrained, multifunctional genes.

This study performs GWAS on three molecular traits, identifying core genes and pathways while highlighting a polygenic background contributing to trait variance.

This study identifies 203 genomic regions associated with facial variation using GWAS on multivariate shape phenotypes, revealing novel regions and epistatic interactions.

This study identifies shared genetic loci influencing brain and facial shape, distinct from cognitive traits, suggesting a developmental link between brain and face formation.

The paper uses miRNA target site analysis to show preexisting gene dosage sensitivities influenced the evolution of mammalian and avian sex chromosomes.