Concomitant ablation of SOS1 and SOS2 triggers a lethal phenotype involving compromised intestinal integrity and widespread septicemia
Andrea Olarte-San Juan, Pablo Rodríguez-Ramos, Alba Díaz-Aguilera, Nuria Calzada, Carmela Gómez, Rocío Fuentes‐Mateos, Alberto Fernández‐Medarde, Rubén Nogueiras, David Díaz, Eugenio Santos, Rósula García‐Navas
This study shows that deleting both SOS1 and SOS2 in mice causes intestinal damage, bacterial leakage, and septicemia, but stemness-enhancing therapies improve survival.
Cell Death and Disease · Aug 12, 2026Peer-reviewedCell Biology