Rubén Nogueiras

Adipocyte MKK3 Increases in Human Obesity protecting against Insulin Resistance by p38-beta activation

The paper investigates the role of MKK3 in adipose tissue during obesity, finding that its activation protects against insulin resistance by enhancing p38-beta signaling.

Concomitant ablation of SOS1 and SOS2 triggers a lethal phenotype involving compromised intestinal integrity and widespread septicemia

This study shows that deleting both SOS1 and SOS2 in mice causes intestinal damage, bacterial leakage, and septicemia, but stemness-enhancing therapies improve survival.

Inhibition of p107 alleviates liver steatosis by reducing de novo fatty acid synthesis.

This study shows that inhibiting p107 reduces liver steatosis by lowering de novo fatty acid synthesis and enhancing mitochondrial function in both mouse models and human hepatocytes.

Ciliary sensing in tanycytes couples nutrient availability to metabolic regulation

This study shows that tanycytic cilia sense metabolic cues in the cerebrospinal fluid, affecting energy balance and metabolism in mice.

The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis

The paper investigates SARS-CoV-2 infection in the hypothalamus and associated regions, showing viral entry receptors and susceptibility factors linked to neurological symptoms in COVID-19.

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency

This study demonstrates that gene therapy targeting brain endothelial cells improves neurological symptoms in a mouse model of MCT8 deficiency by increasing brain T3 levels and motor function.