Reinoud Gosens

Modelling cigarette smoke-induced lung vascular dysfunction using an alveolus-on-chip

This paper presents an alveolus-on-chip model to study vascular-epithelial interactions and smoke-induced lung injury, showing that cigarette smoke disrupts vascular networks when exposed to alveolar epithelial cells.

cGAS-STING drives alveolar epithelial cell dysfunction in cigarette smoke-induced lung injury

This study shows that cGAS-STING activation in alveolar epithelial cells impairs regeneration and differentiation in response to cigarette smoke exposure.

Fibroblast-derived osteoglycin promotes epithelial cell repair

The paper identifies fibroblast-derived osteoglycin as a key factor promoting epithelial cell repair and presents its active fragment as a potential therapeutic for lung diseases.

Age-associated Differences in the Human Lung Extracellular Matrix

This study identifies seven age-associated ECM proteins with increased expression in human lung tissue and demonstrates age-related differences in specific lung compartments.

Differentiation of airway cholinergic neurons from human pluripotent stem cells for airway neurobiology studies

This paper develops an in vitro model of human airway cholinergic neurons from pluripotent stem cells to study neuroplasticity in respiratory diseases.